A MySQL server can accept incoming connections from specific IP addresses. By default every MySQL-server listens to local IP address 127.0.0.1, every MariaDB server accepts all connections (i.e. it listens 0.0.0.0). In ISPmanager Lite 5.95 and later you can set up remote access.
Navigate to Settings-> Database servers --> select a server, and click Edit. On the form that will open, enable remote access, and select an IP address.
Creating a database user
User creation and edit procedures will be changed in the course of time. If Remote access is enabled for the server where a user should be located, the corresponding checkbox will be hidden on the user configuration form.